abstract：:Brain renin-angiotensin system (RAS) hyperactivity has been implicated in sympathetic hyperactivity and progressive left ventricular (LV) dysfunction after myocardial infarction (MI). Angiotensin III, generated by aminopeptidase A (APA), is one of the main effector peptides of the brain RAS in the control of cardiac f...

journal_title：Journal of molecular and cellular cardiology

authors： Boitard SE,Marc Y,Keck M,Mougenot N,Agbulut O,Balavoine F,Llorens-Cortes C

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Pulmonary arterial hypertension (PAH) results in right ventricular (RV) failure, electro-mechanical dysfunction and heightened risk of sudden cardiac death (SCD), although exact mechanisms and predisposing factors remain unclear. Because impaired chronotropic response to exercise is a strong predictor of ear...

journal_title：Journal of molecular and cellular cardiology

authors： Strauss B,Sassi Y,Bueno-Beti C,Ilkan Z,Raad N,Cacheux M,Bisserier M,Turnbull IC,Kohlbrenner E,Hajjar RJ,Hadri L,Akar FG

更新日期：2019-02-01 00:00:00

abstract：:Inflammation is critical in the pathobiology of atherosclerosis. An essential player in the inflammatory process in atherosclerosis are macrophages that scavenge oxidatively modified low-density lipoproteins (OxLDL) deposited in the subendothelium of systemic arteries that secrete a myriad of pro-inflammatory mediator...

journal_title：Journal of molecular and cellular cardiology

authors： Chandra D,Londino J,Alexander S,Bednash JS,Zhang Y,Friedlander RM,Daskivich G,Carlisle DL,Lariviere WR,Nakassa ACI,Ross M,St Croix C,Nyunoya T,Sciurba F,Chen B,Mallampalli RK

更新日期：2019-01-01 00:00:00

abstract：RATIONALE:A higher expression/activity of type 1 serine/threonine protein phosphatase 1 (PP1) may contribute to dephosphorylation of cardiac regulatory proteins triggering the development of heart failure. OBJECTIVE:Here, we tested the putatively protective effects of PP1 inhibitor-2 (I2) overexpression using a heart ...

journal_title：Journal of molecular and cellular cardiology

authors： Kirchhefer U,Hammer E,Heinick A,Herpertz T,Isensee G,Müller FU,Neumann J,Schulte K,Seidl MD,Boknik P,Schulte JS

更新日期：2018-12-01 00:00:00

abstract：:Chronic pain aggravates cardiovascular injury via incompletely understood mechanisms. While melatonin may participate in the pathophysiological process of chronic pain, its cardiovascular effects under chronic pain states remains unknown. In this study, chronic pain was induced by spared nerve injury model (SNI) for 4...

journal_title：Journal of molecular and cellular cardiology

authors： Yang Z,Li C,Wang Y,Yang J,Yin Y,Liu M,Shi Z,Mu N,Yu L,Ma H

更新日期：2018-12-01 00:00:00

abstract：:Cardiac tyhrotropin-releasing hormone (TRH) is overexpressed in the hypertrophied left ventricle (LV) of spontaneously hypertensive rats (SHR) and its inhibition prevents both hypertrophy and fibrosis. In a normal heart, the TRH increase induces fibrosis and hypertrophy opening the question of whether TRH could be a c...

journal_title：Journal of molecular and cellular cardiology

authors： Peres Diaz LS,Schuman ML,Aisicovich M,Toblli JE,Pirola CJ,Landa MS,García SI

更新日期：2018-11-01 00:00:00

abstract：:Ischemia-reperfusion (IR) injury occurs when blood supply to an organ is disrupted and then restored, and underlies many disorders, notably myocardial infarction and stroke. While reperfusion of ischemic tissue is essential for survival, it also initiates cell death through generation of mitochondrial reactive oxygen ...

journal_title：Journal of molecular and cellular cardiology

authors： Pell VR,Spiroski AM,Mulvey J,Burger N,Costa ASH,Logan A,Gruszczyk AV,Rosa T,James AM,Frezza C,Murphy MP,Krieg T

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Fabry disease is an X-linked disease caused by mutations in α-galactosidase A (GLA); these mutations result in the accumulation of its substrates, mainly globotriaosylceramide (Gb3). The accumulation of glycosphingolipids induces pathogenic changes in various organs, including the heart, and Fabry cardiomyop...

journal_title：Journal of molecular and cellular cardiology

authors： Kuramoto Y,Naito AT,Tojo H,Sakai T,Ito M,Shibamoto M,Nakagawa A,Higo T,Okada K,Yamaguchi T,Lee JK,Miyagawa S,Sawa Y,Sakata Y,Komuro I

更新日期：2018-08-01 00:00:00

abstract：:The cardiac muscle sarcomere contains multiple proteins contributing to contraction energy transduction and its regulation during a heartbeat. Inheritable heart disease mutants affect most of them but none more frequently than the ventricular myosin motor and cardiac myosin binding protein c (mybpc3). These co-localiz...

journal_title：Journal of molecular and cellular cardiology

authors： Burghardt TP,Ajtai K

更新日期：2018-06-01 00:00:00

abstract：:Changes in the nonischemic remote myocardium of the heart contribute to left ventricular dysfunction after ischemia and reperfusion (I/R). Understanding the underlying mechanisms early after I/R is crucial to improve the adaptation of the viable myocardium to increased mechanical demands. Here, we investigated the rol...

journal_title：Journal of molecular and cellular cardiology

authors： Kronenbitter A,Funk F,Hackert K,Gorreßen S,Glaser D,Boknik P,Poschmann G,Stühler K,Isić M,Krüger M,Schmitt JP

更新日期：2018-06-01 00:00:00

abstract：:Serine 727 (Ser727) phosphorylation of STAT3 plays a role in the regulation of mitochondrial respiration. This study aimed to test if zinc could regulate mitochondrial respiration through phosphorylation of STAT3 at Ser727 in the setting of ischemia/reperfusion in the heart. Under normoxic conditions, treatment of iso...

journal_title：Journal of molecular and cellular cardiology

authors： Zhang G,Sheng M,Wang J,Teng T,Sun Y,Yang Q,Xu Z

更新日期：2018-05-01 00:00:00

abstract：:Contrary to the apoptosis-necrosis binary view of cell death, recent experimental evidence demonstrates that several forms of necrosis, represented by necroptosis, are regulated or programmed in nature. Multiple death stimuli known to be associated with cardiovascular disease are capable of causing either apoptosis or...

journal_title：Journal of molecular and cellular cardiology

authors： Gupta K,Phan N,Wang Q,Liu B

更新日期：2018-05-01 00:00:00

abstract：:Peptidyl-prolyl isomerase Pin1 has been reported to be associated with endothelial dysfunction. However, the role of smooth muscle Pin1 in the vascular system remains unclear. Here, we examined the potential function of Pin1 in smooth muscle cells (SMCs) and its contribution to abdominal aortic aneurysm (AAA) pathogen...

journal_title：Journal of molecular and cellular cardiology

authors： Liang ES,Cheng W,Yang RX,Bai WW,Liu X,Zhao YX

更新日期：2018-01-01 00:00:00

abstract：:Brugada syndrome predisposes to sudden death due to disruption of normal cardiac ion channel function, yet our understanding of the underlying cellular mechanisms is incomplete. Commonly used heterologous expression models lack many characteristics of native cardiomyocytes and, in particular, the individual genetic ba...

journal_title：Journal of molecular and cellular cardiology

authors： Selga E,Sendfeld F,Martinez-Moreno R,Medine CN,Tura-Ceide O,Wilmut SI,Pérez GJ,Scornik FS,Brugada R,Mills NL

更新日期：2018-01-01 00:00:00

abstract：:This study examined the significance of macrophage autophagy in extracellular matrix metalloproteinase inducer (EMMPRIN)-mediated atherosclerosis (AS). Apolipoprotein E-deficient (ApoE-/-) mice were fed a western diet to establish an AS model. EMMPRIN and p62/Sequestosome-1(SQSTM1) expression were evaluated in plaque ...

journal_title：Journal of molecular and cellular cardiology

authors： Liang X,Hou X,Yang Y,Liu H,Guo R,Yang Z,Yang L

更新日期：2018-01-01 00:00:00

abstract：:Since ascorbate is unnecessary for cell growth and survival, cardiac fibroblasts are routinely cultured without it. However, ascorbate is necessary for optimal collagen synthesis, so we hypothesized that its presence would influence cell phenotype. Cardiac fibroblasts cultured without ascorbate had increased intracell...

journal_title：Journal of molecular and cellular cardiology

authors： Cowling RT,Park JI,Sotimehin AE,Greenberg BH

更新日期：2017-12-01 00:00:00

abstract：:Cardiovascular diseases (CVDs) and renal impairment interact in a complex and interdependent manner, which makes clarification of possible pathogenesis between CVDs and renal diseases very challenging and important. There is increasing evidence showing that both asymmetric dimethylarginine (ADMA) and symmetric dimethy...

journal_title：Journal of molecular and cellular cardiology

authors： Hu XL,Li MP,Song PY,Tang J,Chen XP

更新日期：2017-12-01 00:00:00

abstract：:Heart failure is associated with mitochondrial dysfunction so that restoring or improving mitochondrial health is of therapeutic importance. Recently, reduction in NAD+ levels and NAD+-mediated deacetylase activity has been recognized as negative regulators of mitochondrial function. Using a cardiac specific KLF4 defi...

journal_title：Journal of molecular and cellular cardiology

authors： Zhang R,Shen Y,Zhou L,Sangwung P,Fujioka H,Zhang L,Liao X

更新日期：2017-11-01 00:00:00

abstract：:Cardiac ischemia-reperfusion (I/R) injury always accompanies recanalization treatment for myocardial infarction. Here we found soluble epoxide hydrolase (sEH), which metabolizes cardioprotective epoxyeicosatrienoic acids into less effective diols, was rapidly activated during myocardial reperfusion in both mouse and r...

journal_title：Journal of molecular and cellular cardiology

authors： Ding Y,Li Y,Zhang X,He J,Lu D,Fang X,Wang Y,Wang J,Zhang Y,Qiao X,Gan LM,Chen C,Zhu Y

更新日期：2017-09-01 00:00:00

abstract：AIMS:Ischaemic cardiovascular disease is a major cause of morbidity and mortality worldwide. Despite promising results from pre-clinical animal models, VEGF-based strategies for therapeutic angiogenesis have yet to achieve successful reperfusion of ischaemic tissues in patients. Failure to restore efficient VEGF activi...

journal_title：Journal of molecular and cellular cardiology

authors： Kurusamy S,López-Maderuelo D,Little R,Cadagan D,Savage AM,Ihugba JC,Baggott RR,Rowther FB,Martínez-Martínez S,Arco PG,Murcott C,Wang W,Francisco Nistal J,Oceandy D,Neyses L,Wilkinson RN,Cartwright EJ,Redondo JM,Armesi

更新日期：2017-08-01 00:00:00

abstract：:The sodium/potassium ATPase (NKA) is essential for establishing the normal intracellular [Na+] and [K+] and transmembrane gradients that are essential for many cellular functions, including cardiac electrophysiology and contractility. Different NKA isoforms exhibit differential expression levels, cellular localization...

journal_title：Journal of molecular and cellular cardiology

authors： Yuen GK,Galice S,Bers DM

更新日期：2017-07-01 00:00:00

abstract：:Duchenne Muscular Dystrophy (DMD) cardiomyopathy is a progressive lethal disease caused by the lack of the dystrophin protein in the heart. The most widely used animal model of DMD is the dystrophin-deficient mdx mouse; however, these mice exhibit a mild dystrophic phenotype with heart failure only late in life. In co...

journal_title：Journal of molecular and cellular cardiology

authors： Lopez JR,Kolster J,Zhang R,Adams J

更新日期：2017-07-01 00:00:00

abstract：:Cardiac β-adrenergic receptors (β-AR) and Ca2+-Calmodulin dependent protein kinase (CaMKII) regulate both physiological and pathophysiological Ca2+ signaling. Elevated diastolic Ca2+ leak from the sarcoplasmic reticulum (SR) contributes to contractile dysfunction in heart failure and to arrhythmogenesis. β-AR activati...

journal_title：Journal of molecular and cellular cardiology

authors： Pereira L,Bare DJ,Galice S,Shannon TR,Bers DM

更新日期：2017-07-01 00:00:00

abstract：AIMS:LCZ696, a novel angiotensin receptor neprilysin inhibitor, is effective in treating heart failure patients. Doxorubicin (DOX) is an effective antitumor medication but the cardiotoxicity limited its clinical use. In this study, we aimed to determine the effect of LCZ696 on DOX-induced cardiomyopathy in mice and in ...

journal_title：Journal of molecular and cellular cardiology

authors： Xia Y,Chen Z,Chen A,Fu M,Dong Z,Hu K,Yang X,Zou Y,Sun A,Qian J,Ge J

更新日期：2017-07-01 00:00:00

abstract：:Regulator of G protein signalling 2 (RGS2) is known to play a protective role in maladaptive cardiac hypertrophy and heart failure via its ability to inhibit Gq- and Gs- mediated GPCR signalling. We previously demonstrated that RGS2 can also inhibit protein translation and can thereby attenuate cell growth. This G pro...

journal_title：Journal of molecular and cellular cardiology

authors： Lee KN,Lu X,Nguyen C,Feng Q,Chidiac P

更新日期：2017-07-01 00:00:00

abstract：:Pro-inflammatory cytokines are released in septic shock and impair cardiac function via the Jak-STAT pathway. It is well known that sympathetic stimulation leads to coupling of the β-adrenergic receptor/Gs/adenylyl cyclase, a membrane-bound enzyme that catalyzes the conversion of ATP to cAMP, thereby stimulating prote...

journal_title：Journal of molecular and cellular cardiology

authors： Jin H,Fujita T,Jin M,Kurotani R,Namekata I,Hamaguchi S,Hidaka Y,Cai W,Suita K,Ohnuki Y,Mototani Y,Shiozawa K,Prajapati R,Liang C,Umemura M,Yokoyama U,Sato M,Tanaka H,Okumura S,Ishikawa Y

更新日期：2017-07-01 00:00:00

abstract：:The endoplasmic reticulum (ER) forms discrete junctions with the plasma membrane (PM) that play a critical role in the regulation of Ca2+ signaling during cellular bioenergetics, apoptosis and autophagy. We have previously confirmed that acetylcholine can inhibit ER stress and apoptosis after inflammatory injury. Howe...

journal_title：Journal of molecular and cellular cardiology

authors： Zhao M,Jia HH,Liu LZ,Bi XY,Xu M,Yu XJ,He X,Zang WJ

更新日期：2017-06-01 00:00:00

abstract：:The transformation of vascular smooth muscle cells [VSMC] into foam cells leading to increased plaque size and decreased stability is a key, yet understudied step in atherogenesis. We reported that Interleukin-19 (IL-19), a novel, anti-inflammatory cytokine, attenuates atherosclerosis by anti-inflammatory effects on V...

journal_title：Journal of molecular and cellular cardiology

authors： Gabunia K,Herman AB,Ray M,Kelemen SE,England RN,DeLa Cadena R,Foster WJ,Elliott KJ,Eguchi S,Autieri MV

更新日期：2017-04-01 00:00:00

abstract：:Functional impact of cardiac ryanodine receptor (type 2 RyR or RyR2) phosphorylation by protein kinase A (PKA) remains highly controversial. In this study, we characterized a functional link between PKA-mediated RyR2 phosphorylation level and sarcoplasmic reticulum (SR) Ca2+ release and leak in permeabilized rabbit ve...

journal_title：Journal of molecular and cellular cardiology

authors： Bovo E,Huke S,Blatter LA,Zima AV

更新日期：2017-03-01 00:00:00

abstract：:The intracellular fibroblast growth factors (iFGF/FHFs) bind directly to cardiac voltage gated Na+ channels, and modulate their function. Mutations that affect iFGF/FHF-Na+ channel interaction are associated with arrhythmia syndromes. Although suspected to modulate other ionic currents, such as Ca2+ channels based on ...

journal_title：Journal of molecular and cellular cardiology

authors： Wang X,Tang H,Wei EQ,Wang Z,Yang J,Yang R,Wang S,Zhang Y,Pitt GS,Zhang H,Wang C

更新日期：2017-03-01 00:00:00

abstract：:Doxorubicin (DOX)-induced cardiotoxicity has been a well-known phenomenon to clinicians and scientists for decades; however, molecular mechanisms underlying DOX cardiotoxicity are still being uncovered. Although the majority of prior research have implicated nuclear and mitochondrial events to be an important etiologi...

journal_title：Journal of molecular and cellular cardiology

authors： Bartlett JJ,Trivedi PC,Pulinilkunnil T

更新日期：2017-03-01 00:00:00

abstract：:Familial hypertrophic cardiomyopathy (HCM), linked to mutations in myosin, myosin-binding proteins and other sarcolemmal proteins, is associated with increased risk of life threatening ventricular arrhythmias, and a number of animal models have been developed to facilitate analysis of disease progression and mechanism...

journal_title：Journal of molecular and cellular cardiology

authors： Hueneke R,Adenwala A,Mellor RL,Seidman JG,Seidman CE,Nerbonne JM

更新日期：2017-02-01 00:00:00

abstract：:Serine/threonine protein phosphatases control dephosphorylation of numerous cardiac proteins, including a variety of ion channels and calcium-handling proteins, thereby providing precise post-translational regulation of cardiac electrophysiology and function. Accordingly, dysfunction of this regulation can contribute ...

journal_title：Journal of molecular and cellular cardiology

authors： Heijman J,Ghezelbash S,Wehrens XH,Dobrev D

更新日期：2017-02-01 00:00:00

abstract：:During systole, Ca2+ is released from the sarcoplasmic reticulum (SR) through ryanodine receptors (RyRs) while, simultaneously, other ions (specifically K+, Mg2+, and Cl-) provide counter-ion flux. These ions move back into the SR during diastole through the SERCA pump and SR K+ and Cl- channels. In homeostasis, all i...

journal_title：Journal of molecular and cellular cardiology

authors： Berti C,Zsolnay V,Shannon TR,Fill M,Gillespie D

更新日期：2017-02-01 00:00:00

abstract：:Cinnamaldehyde (CA), a major bioactive compound extracted from the essential oil of Cortex Cinnamomi, exhibits anti-inflammatory activity on endotoxemia. Accumulating evidence indicates reactive oxygen species (ROS) and autophagy play a vital role in the cardiac dysfunction during endotoxemia. The aim of this study wa...

journal_title：Journal of molecular and cellular cardiology

authors： Zhao H,Zhang M,Zhou F,Cao W,Bi L,Xie Y,Yang Q,Wang S

更新日期：2016-12-01 00:00:00

abstract：AIMS:Biglycan, a small leucine-rich proteoglycan, has been shown to play an important role in stabilizing fibrotic scars after experimental myocardial infarction. However, the role of biglycan in the development and regression of cardiomyocyte hypertrophy and fibrosis during cardiac pressure overload and unloading rema...

journal_title：Journal of molecular and cellular cardiology

authors： Beetz N,Rommel C,Schnick T,Neumann E,Lother A,Monroy-Ordonez EB,Zeeb M,Preissl S,Gilsbach R,Melchior-Becker A,Rylski B,Stoll M,Schaefer L,Beyersdorf F,Stiller B,Hein L

更新日期：2016-12-01 00:00:00

abstract：:Thoracic aortic aneurysm/dissection (TAAD) is characterized by excessive smooth muscle cell (SMC) loss, extracellular matrix (ECM) degradation and inflammation. However, the mechanism whereby signaling leads to SMC loss is unclear. We used senescence-associated (SA)-β-gal staining and analysis of expression of senesce...

journal_title：Journal of molecular and cellular cardiology

authors： Zhang WM,Liu Y,Li TT,Piao CM,Liu O,Liu JL,Qi YF,Jia LX,Du J

更新日期：2016-10-01 00:00:00

abstract：:Retinoic acid receptor (RAR) has been implicated in pathological stimuli-induced cardiac remodeling. To determine whether the impairment of RARα signaling directly contributes to the development of heart dysfunction and the involved mechanisms, tamoxifen-induced myocardial specific RARα deletion (RARαKO) mice were uti...

journal_title：Journal of molecular and cellular cardiology

authors： Zhu S,Guleria RS,Thomas CM,Roth A,Gerilechaogetu F,Kumar R,Dostal DE,Baker KM,Pan J

更新日期：2016-10-01 00:00:00

abstract：RATIONALE:Circulating monocytes play pivotal roles in chronic inflammatory diseases. Epoxyeicosatrienoic acids (EETs), metabolites of arachidonic acid, are known to have anti-inflammatory effects and are hydrolyzed by soluble epoxide hydrolase (sEH). OBJECTIVE:We aimed to investigate the effect of sEH inhibition in at...

journal_title：Journal of molecular and cellular cardiology

authors： Li D,Liu Y,Zhang X,Lv H,Pang W,Sun X,Gan LM,Hammock BD,Ai D,Zhu Y

更新日期：2016-09-01 00:00:00

abstract：:Small antisense RNAs like miRNA and siRNA are of crucial importance in cardiac physiology, pathology and, moreover, can be applied as therapeutic agents for the treatment of cardiovascular diseases. Identification of novel strategies for miRNA/siRNA therapy requires a comprehensive understanding of the underlying mech...

journal_title：Journal of molecular and cellular cardiology

authors： Lemcke H,Peukert J,Voronina N,Skorska A,Steinhoff G,David R

更新日期：2016-09-01 00:00:00